Quantitative Spectrophotometric Determination of Ornidazole Tablet Formulations Using Ibuprofen Sodium as Hydrotropic Solubilizing Agent

Various techniques are employed to enhance the aqueous solubility of poorly watersoluble drugs and hydrotropic solubilization is one of them. In the present investigation, hydrotropic solution of ibuprofen sodium (0.5M) was employed as solubilizing agent to solubilize the poorly water-soluble drug, ornidazole from fine power of its tablets for spectrophotometric determination. Ornidazole shows its maximum absorbance at 320 nm and Beer’s law was obeyed in concentration range of 5-25 mcg/ml. Results of analysis were validated statistically and by recovery studies. The proposed method is new, simple, safe, environmentally friendly, accurate and cost-effective and can be successfully employed in routine to analyze ornidazole tablets. Hydrotropic agent and commonly used tablet additives did not interfere in the analysis.